The space between us: Modeling spatial heterogeneity in synthetic microbial consortia dynamics

The space between us: Modeling spatial heterogeneity in synthetic microbial consortia dynamics

Blog Article

A central endeavor in bioengineering concerns the construction of multistrain microbial consortia with desired properties.Typically, a gene network is partitioned WATER BUFFALO BUTTER UNSALTED between strains, and strains communicate via quorum sensing, allowing for complex behaviors.Yet a fundamental question of how emergent spatiotemporal patterning in multistrain microbial consortia affects consortial dynamics is not understood well.

Here, we propose a computationally tractable and straightforward modeling framework that explicitly allows linking spatiotemporal patterning to consortial dynamics.We validate our model against previously published results and make predictions of how spatial Christmas Sack heterogeneity impacts interstrain communication.By enabling the investigation of spatial patterns effects on microbial dynamics, our modeling framework informs experimentalists, helps advance the understanding of complex microbial systems, and supports the development of applications involving them.